Novel 10-Bit Impedance-to-Digital Converter for Electrochemical Impedance Spectroscopy Measurements.

Electrochemical impedance spectroscopy (EIS) is a widely used technique in biomedical and chemical analysis. A novel 10-bit impedance-to-digital converter (IDC), which can measure and directly convert the magnitude and phase of impedance to digital codes, is proposed for the EIS measurement system. The proposed IDC is composed of a magnitude-to-digital converter (MDC) and a phase-to-digital converter (PDC). The proposed IDC was designed and fabricated using a 0.35 [Formula: see text] 2P4M mixed-signal polycide process, and the core area is only 0.07 mm2 . Moreover, it can work over a very wide frequency range (0.1 mHz-100 kHz), and has excellent accuracy. According to the measured results, the DNL of the MDC is within -0.3/+0.3 LSB, and the INL is around -3/+1 LSB. Moreover, an EIS measurement system, which is composed of the proposed IDC chip and some other commercial chips, is built to measure ZoBell's and melatonin solutions for validating the function of the proposed IDC.