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Journal Article
Research Support, N.I.H., Extramural
Review
Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy.
Clinics in Liver Disease 2017 Februrary
In this article, we review the past applications of in vitro models in identifying human hepatotoxins and then focus on the use of multiscale experimental models in drug development, including the use of zebrafish and human cell-based, 3-dimensional, microfluidic systems of liver functions as key components in applying Quantitative Systems Pharmacology (QSP). We have implemented QSP as a platform to improve the rate of success in the process of drug discovery and development of therapeutics.
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