[Neurocognitive Performance in Euthymic Bipolar I Patients With and Without History of Psychosis From a Multimodal Intervention Program: PRISMA].

BACKGROUND: Patients with bipolar disorder type I (BDI) have an increased prevalence of psychotic symptoms, and these have been associated with higher cognitive impairment; however the issue has not been settled with the available evidence.

OBJECTIVE: To determine if the history of psychotic symptoms in a Colombian sample with BDI is associated with greater cognitive impairment.

METHODS: A case-control study was performed that included patients with BDI from the l PRISMA study. Of the 203 eligible subjects, 123 participants were included; 71 had a history of psychosis, and 52 did not. Cognitive function was characterised by neuropsychological tests that assessed intellectual coefficient, attention, executive function, verbal fluency, auditory and visual memory, and spatial location.

RESULTS: No differences were found in most of the neuropsychological test results between the groups after adjusting for age, education, sex, duration of the disease, number of episodes, and use of benzodiazepines; however, there was differences in semantic FAS (P=.01), with a better performance in the group with a prior history of psychosis.

CONCLUSIONS: The results suggest that there are no significant differences in the cognitive performance between patients with BDI in euthymic stage, with and without history of psychosis.