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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
Regulation of IP 3 receptors by cyclic AMP.
Cell Calcium 2017 May
Ca2+ and cAMP are ubiquitous intracellular messengers and interactions between them are commonplace. Here the effects of cAMP on inositol 1,4,5-trisphosphate receptors (IP3 Rs) are briefly reviewed. All three subtypes of IP3 R are phosphorylated by cAMP-dependent protein kinase (PKA). This potentiates IP3 -evoked Ca2+ release through IP3 R1 and IP3 R2, but probably has little effect on IP3 R3. In addition, cAMP can directly sensitize all three IP3 R subtypes to IP3 . The high concentrations of cAMP required for this PKA-independent modulation of IP3 Rs is delivered to them within signalling junctions that include type 6 adenylyl cyclase and IP3 R2.
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