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Case Reports
Journal Article
Isolated Nonsyndromic Intraneural Neuroma of the Eyelid Skin.
Ophthalmic Plastic and Reconstructive Surgery 2016 November
A 56-year-old man developed a 2 × 2 mm, yellow-orange painless, smooth-surfaced nodule in the middle third of his left upper eyelid. Microscopic evaluation disclosed a spindle cell tumor that was well circumscribed by a perineurium. The tumor cells manifested wavy, bland nuclei displaying comma-shaped and pointed ends. These cells were uniformly S100 positive. Immunohistochemical analysis further revealed an even dispersion of numerous dot-like neurofilaments diagnostic of an isolated intraneural neuroma. A neuroma differs from a schwannoma which fails to exhibit neurofilaments except in a peripherally located compressed nerve of origin. Simple excision is recommended.
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