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Viral metagenomics of fecal samples from non-human primates revealed human astrovirus in a chimpanzee, China.
Gut Pathogens 2016
BACKGROUND: Human astroviruses (HAstVs) are commonly identified worldwide as important aetiological agents of acute gastroenteritis in all age groups. More and more evidences challenged the paradigm that AstV infections are species-specific. Yet to date, AstVs associated with human infections have not been detected in any animal hosts.
RESULTS: Viral metagenomics methods were used to detect viral nucleic acids in fecal samples from 69 captive non-human primates (NHPs) from three zoos in China. Sequence reads showing high similarity to astrovirus MLB2 were found in feces from a chimpanzee with diarrhea. The complete genome of this astrovirus was determined and deposited in the GenBank under accession number KX273058 (named SAstV-nj). Phylogenetic analysis based on complete genomes revealed that SAstV-nj was closely related to and shared >98% nucleotide sequence identity with the previous human astrovirus MLB2 strains.
CONCLUSIONS: This study suggested that MLB2-related astroviruses might have the potential of cross-species transmission between human and NHP.
RESULTS: Viral metagenomics methods were used to detect viral nucleic acids in fecal samples from 69 captive non-human primates (NHPs) from three zoos in China. Sequence reads showing high similarity to astrovirus MLB2 were found in feces from a chimpanzee with diarrhea. The complete genome of this astrovirus was determined and deposited in the GenBank under accession number KX273058 (named SAstV-nj). Phylogenetic analysis based on complete genomes revealed that SAstV-nj was closely related to and shared >98% nucleotide sequence identity with the previous human astrovirus MLB2 strains.
CONCLUSIONS: This study suggested that MLB2-related astroviruses might have the potential of cross-species transmission between human and NHP.
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