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Slip slidin' away of mitosis with CRL2Zyg11.
Journal of Cell Biology 2016 October 25
The spindle assembly checkpoint arrests mitotic cells by preventing degradation of cyclin B1 by the anaphase-promoting complex/cyclosome, but some cells evade this checkpoint and slip out of mitosis. Balachandran et al. (2016. J. Cell Biol. https://dx.doi.org/10.1083/jcb.201601083) show that the E3 ligase CRL2(ZYG11) degrades cyclin B1, allowing mitotic slippage.
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