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An intracellular protein delivery platform based on glutathione-responsive protein nanocapsules.
Chemical Communications : Chem Comm 2016 November 16
An efficient strategy for the intracellular delivery of proteins was developed based on assembling proteins with a self-crosslinkable polymer. Such a disulfide-crosslinking structure enhances the stability of the protein-polymer assembly, and also allows effective dissociation of the assembly in response to glutathione, which allows effective delivery of various proteins with high intracellular bioactivity.
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