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Variations in Vitamin D Receptor Gene, Adiposity Phenotypes and Metabolic Profile in Overweight Women with Hypovitaminosis D.

BACKGROUND: The possible role of vitamin D receptor (VDR) genotypes in determining adiposity phenotypes and cardiovascular risk factors has been suggested previously. The aim of this study was to evaluate the associations of the VDR gene variants with adiposity phenotypes and metabolic profile in Iranian overweight women with hypovitaminos is D.

METHODS: Three VDR variants including FokI (rs2228570), BsmI (rs1544410) and rs757343 were detected using PCR-sequencing. Metabolic Profile including fasting plasma glucose, total cholesterol, LDL-C, HDL-C, and triacylglycerol were assessed using commercial kits. Circulating 25 (OH) D was measured using ELISA kits. Fat mass and visceral fat were measured using Bio Impedance Analysis.

RESULTS: A sample of 123 overweight women with hypovitaminosis D (25 (OH) D<75nmol/L) was studied. The mean 25 (OH) D level was 28.7±17.0nmol/L. The FokI polymorphism was significantly associated with total cholesterol (p=0.03) and LDL-C (p=0.01). Carriers of the CC genotype of the FokI polymorphism had lower total cholesterol (162.9±30.4 vs. 176.1±32.4, p=0. 02) and LDL-C (98.0±26.0 vs. 110.6±28.5, p=0. 01) compared with carriers of CT+TT genotype. Regression analysis revealed that the FokI variant and fat mass explained 18% of the variance in total cholesterol. Regarding LDL-C, FokI variant explained 21% of the variance in LDL-C. None of the studied polymorphisms were significantly associated with adiposity phenotypes (p>0.05). Also, adiposity phenotype measures were not significantly different in the genotype groups of the studied SNPs (p>0.5).

CONCLUSIONS: The present results indicate that the FokI polymorphism is significantly associated with total cholesterol and LDL-C in Iranian overweight women with hypovitaminosis D.

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