Gilles de la Tourette's and the Disruption of Interneuron-Mediated Synchrony : Comments on: Hashemiyoon, R., Kuhn, J., Visser-Vandewalle, V. Brain Topography (2016). DOI 10.1007/s10548-016-0525-z.

The article by Hashemiyoon et al. is a masterful synthesis of the clinical, genetic, and neurobiological aspects of Gilles de la Tourette's syndrome that provides unique insights into the neural state dysfunctions that underlie this enigmatic disorder. In particular, the authors make a powerful argument for the disorder arising from hyposynchronization within cortico-basal ganglia-thalamocortical systems which may result from a genetically-driven developmental insult to interneuron regulation, and suggest deep brain stimulation as a valuable tool to assess how balance may be restored to the system and reverse the pathological state.