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Hypoxic regulation of neutrophil function and consequences for Staphylococcus aureus infection.

Katharine M Lodge, A A Roger Thompson, Edwin R Chilvers, Alison M Condliffe
Microbes and Infection 2017 March
Staphylococcal infection and neutrophilic inflammation can act in concert to establish a profoundly hypoxic environment. In this review we summarise how neutrophils and Staphylococcus aureus are adapted to function under hypoxic conditions, with a particular focus on the impaired ability of hypoxic neutrophils to effect Staphylococcus aureus killing.

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