Add like
Add dislike
Add to saved papers

[Progress in diagnosis and therapy of extrahepatic manifestations of cholestatic liver diseases].

Extra-hepatic complications of cholestasis mainly include pruritus, fatigue and metabolic bone diseases, and their molecular mechanisms have not yet been fully identified so far. Though therapeutic regimens targeted at the pathogenesis alleviate the symptoms temporarily, the therapeutic effects are limited, and therefore expounding the pathogenesis will help find more appropriate therapeutic approaches. Pruritus may be caused by nerve conduction block resulting from accumulation of some substances in the accumulated bile, existing recommended methods like drug therapy with cholestyramine and blood purification can markedly alleviate cholestasis-induced pruritus. Fatigue may be a consequence of the central nervous system disorders, and there is currently no specific therapy. Metabolic bone diseases (MBD), also known as hepatic osteodystrophy, are often manifested by osteopenia and osteoporosis, and correcting bad factors responsible for bone loss will help relieve MBD. Bisphosphonate is recommended for treatment of cholestasis-induced osteoporosis. In the event that a patient experiences intolerable pruritus and frequent fractures resulting from osteoporosis, assessment for liver transplantation should be conducted.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app