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Journal Article
Review
Targeting mutant p53 through the mevalonate pathway.
Nature Cell Biology 2016 October 28
It is well established that mutant forms of the p53 tumour suppressor acquire pro-oncogenic activities. Inhibition of the mevalonate pathway is now shown to promote degradation of select oncogenic mutant p53 proteins, indicating that destabilization of mutant p53 could be a promising therapeutic strategy.
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