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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Novel Fluorescein-Based Fluorescent Probe for Detecting H 2 S and Its Real Applications in Blood Plasma and Biological Imaging.
Analytical Chemistry 2016 November 16
A broad-spectrum fluorescent probe, which can be applied to monitoring H2 S in various biological systems, has been rationally designed and synthesized. This specific probe was applied to localize the endogenous H2 S in living Raw264.7 macrophage cells, HepG2 cells, and H9C2 cells. At the same time, the probe has successfully visualized CBS- and CSE-induced endogenous H2 S production and monitored CBS and CSE activity in H9C2 cells. This probe could serve as a powerful molecular imaging tool to further explore the physiological function and the molecular mechanisms of endogenous H2 S in living animal systems.
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