Significance of change of retinol binding protein 4 level of plasma of patients with coronary heart disease complicated with hyperlipidemia.

OBJECTIVE: We investigated the significance of a change in retinol binding protein (RBP4) levels in the plasma of patients with coronary heart disease complicated with hyperlipidemia.

PATIENTS AND METHODS: 66 cases of coronary heart disease (CHD) patients in Cardiovascular Department of our Hospital from December 2014 to December 2015 were selected. Based on the diagnostic criteria of hyperinsulinemia, patients were divided into a CHD Group with 35 cases and a CHD-Hyperinsulinemia Group (CHD-H group) with 31 cases. 35 healthy adults who had a physical examination in our hospital medical center during the same period were selected as the control group.

RESULTS: Changes in fasting plasma glucose (FPG), uric acid (UA), high sensitive C-reactive protein (hs-CRP), free fatty acid (FFA), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), insulin, RBP4 and HOMA-IR were measured in the plasma of the subjects of the 3 groups, and the correlation of RBP4 levels and other indicators were analyzed. UA, hs-CRP, TG and HDL-C in the CHD group and the CHD-H group were significantly higher than those in the control group (p<0.05), in which the UA level of CHD-H group was higher than that of CHD group (p<0.05). The level of LDL-C in CHD group was higher than that in control group (p<0.05); FIns, 2h PIns, HOMA-IR and RBP4 of CHD-H group were significantly higher than those of the control group and CHD group (p<0.05); 2h PIns and HOMA-IR are independent related factors of RBP4.

CONCLUSIONS: The level of BRP4 in plasma of CHD patients with high insulin was increased. BRP4 was also found to participate in the occurrence of insulin resistance, which may indicate its role as a potential biomarker which identifies cases of insulin resistance of CHD patients and is worth further study.