Clinical significance of dynamic changes in hs-CRP and ADAMTS13 levels in the blood serum of patients with no-reflow after PCI operation.

OBJECTIVE: To evaluate the clinical significance dynamic changes in hs-CRP and ADAMTS13 levels in patients with no-reflow after PCI operation.

PATIENTS AND METHODS: 156 patients with STEMI single-vessel were enrolled in this study. Patients were divided into the reflow and the no-reflow groups. ADAMTS13 and hs-CRP levels were compared between the two groups.

RESULTS: ADAMTS13 and hs-CRP levels in the no-reflow group were significantly lower than those in the reflow group after PCI operation. The ADAMTS13 level in the reflow group peaked at 3 h and then dropped. The ADAMTS13 level was not changed significantly in the no-reflow group and reflow group before and after the operation. In the reflow group, serum hs-CRP level fell sharply within 3 h after operation, while in the no-reflow group it was decreased within 3 h to 3 days after the operation. After the operation, LVEDD was decreased significantly in both groups compared to that of before PCI, but the difference between two groups was not statistically significant. CTFC (frame) and WMSI levels in the reflow group were significantly lower than those in the no-reflow group after the operation, and the differences were statistically significant.

CONCLUSIONS: ADAMTS13 and hs-CRP levels in patients with STEMI were negatively correlated and this correlation was independent from LVDD, LVEF, BMI, WMSI, MAP, LDL, HDL and other factors which can influence STEMI reflow after the operation. Results obtained from the present study provides a valuable theoretical basis for the drug research and development as well as future studies on the no-reflow phenomenon. It also offers an important clinical application value.