JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
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M-DNA/Transition Metal Dichalcogenide Hybrid Structure-based Bio-FET sensor with Ultra-high Sensitivity.

Scientific Reports 2016 October 25
Here, we report a high performance biosensor based on (i) a Cu2+ -DNA/MoS2 hybrid structure and (ii) a field effect transistor, which we refer to as a bio-FET, presenting a high sensitivity of 1.7 × 103  A/A. This high sensitivity was achieved by using a DNA nanostructure with copper ions (Cu2+ ) that induced a positive polarity in the DNA (receptor). This strategy improved the detecting ability for doxorubicin-like molecules (target) that have a negative polarity. Very short distance between the biomolecules and the sensor surface was obtained without using a dielectric layer, contributing to the high sensitivity. We first investigated the effect of doxorubicin on DNA/MoS2 and Cu2+ -DNA/MoS2 nanostructures using Raman spectroscopy and Kelvin force probe microscopy. Then, we analyzed the sensing mechanism and performance in DNA/MoS2 - and Cu2+ -DNA/MoS2 -based bio-FETs by electrical measurements (ID -VG at various VD ) for various concentrations of doxorubicin. Finally, successful operation of the Cu2+ -DNA/MoS2 bio-FET was demonstrated for six cycles (each cycle consisted of four steps: 2 preparation steps, a sensing step, and an erasing step) with different doxorubicin concentrations. The bio-FET showed excellent reusability, which has not been achieved previously in 2D biosensors.

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