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Development of a Potent and Selective HDAC8 Inhibitor.
ACS Medicinal Chemistry Letters 2016 October 14
A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.
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