JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL
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Salbutamol effects on systemic potassium dynamics during and following intense continuous and intermittent exercise.

PURPOSE: Salbutamol inhalation is permissible by WADA in athletic competition for asthma management and affects potassium regulation, which is vital for muscle function. Salbutamol effects on arterial potassium concentration ([K+ ]a ) during and after high-intensity continuous exercise (HIcont ) and intermittent exercise comprising repeated, brief sprints (HIint ), and on performance during HIint are unknown and were investigated.

METHODS: Seven recreationally active men participated in a double-blind, randomised, cross-over design, inhaling 1000 µg salbutamol or placebo. Participants cycled continuously for 5 min at 40 % [Formula: see text]O2peak and 60 % [Formula: see text]O2peak , then HIcont (90 s at 130 % [Formula: see text]O2peak ), 20 min recovery, and then HIint (3 sets, 5 × 4 s sprints), with 30 min recovery.

RESULTS: Plasma [K+ ]a increased throughout exercise and subsequently declined below baseline (P < 0.001). Plasma [K+ ]a was greater during HIcont than HIint (P < 0.001, HIcont 5.94 ± 0.65 vs HIint set 1, 4.71 ± 0.40 mM); the change in [K+ ]a from baseline (Δ[K+ ]a ) was 2.6-fold greater during HIcont than HIint (P < 0.001). The Δ[K+ ] throughout the trial was less with salbutamol than placebo (P < 0.001, treatment main effect, 0.03 ± 0.67 vs 0.22 ± 0.69 mM, respectively); and remained less after correction for fluid shifts (P < 0.001). The Δ[K+ ] during HIcont was less after salbutamol (P < 0.05), but not during HIint . Blood lactate, plasma pH, and the work output during HIint did not differ between trials.

CONCLUSIONS: Inhaled salbutamol modulated the [K+ ]a rise across the trial, comprising intense continuous and intermittent exercise and recovery, lowering Δ[K+ ] during HIcont . The limited [K+ ]a changes during HIint suggest that salbutamol is unlikely to influence systemic [K+ ] during periods of intense effort in intermittent sports.

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