A simple and sensitive method for determination of tetrahydropalmatine based on a new voltammetric sensor.

In this paper, a simple, low cost, highly sensitive voltammetric method for determination of tetrahydropalmatine was described, which was based on a new electrochemical sensor, poly (L-glutamic acid) functionalized electrochemical reduction graphene oxide modified glassy carbon electrode. The electrochemical behavior of tetrahydropalmatine was investigated in detail and some dynamic parameters of electrode process were calculated for the first time. Due to large surface area and good conductivity of proposed sensor, a wider linear range (3.0×10-7 -2.0×10-5 molL-1 ) and lower detection limit (1.0×10-7 molL-1 ) were achieved for determination of tetrahydropalmatine. Meanwhile, the proposed method was used in determination of tetrahydropalmatine in Rhizoma Corydalis with well results.