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In the Middle of a Chain Interaction.

Sinéad Kinsella, Jochen H M Prehn
Molecular Cell 2016 October 21
In this issue of Molecular Cell, Fu et al. (2016) present a detailed structural analysis of death-inducing signaling complex (DISC) assembly and regulation through flexible caspase-8 interactions with cFLIPL , cFLIPS , and the viral inhibitor MC159, thereby identifying novel apoptosis control mechanisms.

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