[The clinical analysis of 18 cases with bilateral lung transplantation for severe idiopathic pulmonary arterial hypertension].

Objective: To study the clinical efficacy of bilateral lung transplantation treating for severe idiopathic pulmonary hypertension (IPAH). Methods: The clinical data of 18 cases of bilateral lung transplantation for severe IPAH were retrospectively analyzed. Comparative analysis of preoperative and postoperative sets of data was performed. Results: The postoperative 30-day mortality of 18 cases was 11.1%, 3 months mortality 22.2%. The survival rate of 1 year, 3 years, 5 years was 77.8%, 72.2% and 72.2%, respectively. The remaining 13 cases were able to survive for a long time which preoperative cardiac function rating of level Ⅲ, Ⅳ were improved to level Ⅰafter transplantation. Compared preoperative with postoperative, pulmonary artery systolic pressure from preoperative 128.2±25.6 mmHg dropped to postoperative 39.7±14.8 mmHg; pulmonary artery mean pressure from 75.5±13.94 mmHg to 19.61±6.43 mmHg; right atrial pressure from 21.5±2.43 mmHg to 5.22±4.18 mmHg, all P <0.000 1. Conclusion: Bilateral lung transplantation is an effective treatment for severe idiopathic pulmonary arterial hypertension, which has longer survival.