OS 37-03 IMPACT OF CHANGE IN EXERCISE DOSE ON RISK OF NEWLY DEVELOPED HYPERTENSION AND DIABETES MELLITUS IN KOREAN MEN.

OBJECTIVE: Regular exercise is recommended for prevention and treamtent of hypertension and diabetes mellitus (DM). The objective of this study is to investigate the impact of change in exercise dose on newly devloping hypertension and DM in middle-aged Korean men.

DESIGN AND METHOD: The study population consisted of individuals who participated in a comprehensive health screening program at Kangbuk Samsung Hospital, Seoul, Korea from 2002 to 2014 (N = 233,676) Among them, excluded history of diabetes, hypertnsion, cardiovascular disease and cancer, finally 174, 314 subjects were enrolled in this analysis (mean fu: 5.22 years; median 4.23, IQR 2.12 to 7.89 years) We assessed the weekly frequency of moderate to vigorous exercise which was assessed using the validated Korean version of the International Physical Activity Questionnaire Short Form (IPAQ-SF) and risk of new hypertensio or DM.

RESULTS: During follow-up duration, 5,544 newly developed DM and 21,276 newly developed hypertension were diagnosed.There was no significant association between baseline frequency of regular exercise and incidence of new hypertension and DM during follow-up (P for trend = 0.05 and 0.10, respectively).But, for analysis of change of exercise dose, we classified to three groups according to change of exercise dose: decrease (A), no change (B) and increase (C) per week, respectively. Compared with subjects in A group, those in C group showed significantly lower (7%) risk of newly developed hypertension (multivariate hazard ratio (HR), 0.93; 95% confidence interval (CI), 0.87 to 0.99; P = 0.024) and 17% lower risk of new onset DM (HR, 0.83; 95% CI, 0,74 to 0,92; P = 0,001)).

CONCLUSIONS: Increase in exrecise frequency was significantly associated with lower risk of newly developing hypertension and DM in realtively healthy middle-aged Korean men.