OS 35-01 THE PREVALENCE OF SLEEP APNEA SYNDROME IN PRIMARY ALDOSTERONISM.

OBJECTIVE: Primary aldosteronism (PA) and sleep apnea syndrome (SAS) are common form of secondary hypertension. Some papers reported the group of high risk of SAS was higher rate of complication with PA than that of low risk of SAS. However, there are few reports which evaluated CPAP implementation rate of the PA patients with SAS diagnosing by Polysomnography (PSG). We aim to clarify clinical characteristics of patients of PA with SAS.

DESIGN AND METHOD: We screened with Apnomonitor 284 PA patients who underwent adrenal venous sampling (AVS). 144 cases with high score of apnea hypopnea index (AHI) or oxygen desaturation index (ODI) were examined by PSG to decide application of CPAP. We compared systolic blood pressure (SBP), diastolic blood pressure (DBP), plasma aldosterone concentration (PAC), plasma renin activity (PRA), PAC/PRA ratio (ARR) body mass index (BMI) and AHI.

RESULTS: AHI: 30.7 ± 2.3/hr(Average ± SEM). 68 PA patients were severe SAS (302, was significantly correlated with AHI (r = 0.3568, P < 0.001). SBP: 150.2 ± 1.2 mmHg, DBP: 94.0 ± 0.9 mmHg, PAC: 26.5 ± 1.1 ng/dl, PRA: 0.35 ± 0.02 ng/ml/hr and ARR: 164.6 ± 11.1 ng/dl per ng/ml/hr were not significantly correlated with AHI.

CONCLUSIONS: This study demonstrated the high prevalence rate of SAS in PA patients. To detect a SAS complication, the screening by apnomonitor and PSG should be performed in PA patients.