JS ISH-ECCR-1 MICRORNA, ACE AND CARDIOVASCULAR PROTECTION.

Coding regions of the genome account for less than 2% of the entire human DNA. Our hypothesis is that genetic mechanism besides coding genes are likely to contribute to BP regulation. Non-coding RNAs (ncRNAs) are emerging as key players of transcription regulation in both health and disease states. They control basic functions in virtually all cell types relevant to the cardiovascular system and, thus, a direct involvement with BP regulation is highly probable. Here I review findings on both short and long RNA in human hypertension and the renin-angiotensin system.