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OS 28-05 ANTIHYPERTENSIVE EFFECT OF CHYMASE INHIBITORY JAPANESE WATER PEPPER INTAKE IN SALT-DEPENDENT MODERATE HYPERTENSION MOUSE MODEL AND IN HUMAN.

OBJECTIVE: The aim of this study was to test chymase inhibitory traditional Japanese food (Japanese Water Pepper, JWP) intake in salt-induced hypertensive mouse model and in human.

DESIGN AND METHOD: Salt-dependent hypertension model using 8 weeks age of wild type mice was established giving 2% NaCl drinking water. This model shows chronic moderate hypertension (AJP 2015). Our extensive food extract survey for inhibition of human chymase revealed that JWP possessed human chymase inhibitory effect in vitro. Antihypertensive effect of orally given dried and powdered JWP was examined in above model in vivo. Systolic and diastolic blood pressure post 12 week salt loading in placebo treated group showed significant increase (146/103 mmHg) compared to the starting point at 8 weeks (111/73 mmHg), whereas those in the treated group with JWP (n = 15) showed no significant increase (129/83 mmHg and 748/min) and were equivalent to those in non-salt loading control group except heart rate (n = 20, 124/82 mmHg).

RESULTS: Secondarily, a prospective double blind randomized placebo control clinical trial was performed using dried powered JWP. Mild to moderate hypertensives (n = 36) without taking any antihypertensive drug were recruited and randomly divided into three groups: placebo (n = 13), orally taking dried and powdered JWP 400 (n = 13) or 800 mg/day (n = 13) groups for 12 weeks after at least 2 weeks observation period. Home blood pressure was monitored by an automatic data registering sphygmomanometer in the morning as well as evening. Morning and evening systolic blood pressure of JWP group showed significant reduction before and after the intake of JWP (p < 0.001) and compared to those of control group (p < 0.01). Heart rate of three groups did not change significantly.

CONCLUSIONS: Our results indicated that chymase inhibition by JWP contributed to anti-hypertensive effect in high salt-loading hypertensive mouse model and in human. JWP will be applicable to salt-induced hypertension in human.

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