OS 20-05 IMPACT OF LEFT VENTRICULAR HYPERTROPHY IN HYPERTENSIVE PATIENTS UNDERWENT SUCCESSFUL PERCUTANEOUS CORONARY INTERVENTION WITH DRUG ELUTING STENTS ON LONG-TERM CLINICAL OUTCOMES.

OBJECTIVE: Hypertension (HTN) and its organ damage such as left ventricular hypertrophy (LVH) can lead to worsening heart failure, cardiovascular morbidity and mortality. However, there are limited data regarding the impact of LVH in HTN patients (pts) who underwent successful percutaneous coronary intervention (PCI) with drug eluting stents (DESs) on long-term clinical outcomes.

DESIGN AND METHOD: A total of 1,704 consecutive HTN pts who underwent PCI from 2004 to 2014 were enrolled. The pts were divided into two groups according to the presence of LVH; 1) the LVH group (n = 406) and 2) control group without LVH (n = 1,298). To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Major clinical outcomes were compared between the two groups up to 8 years.

RESULTS: After PSM analysis, two propensity-matched groups (366 pairs, n = 732, C-statistic = 0.629) were generated and the baseline characteristics of the two groups were balanced. For up to 3,000 days, the LVH group showed higher incidence of cardiac death compared with the control group. However, there was no significant difference in the incidence of myocardial infarction, repeat revascularizations and major adverse cardiac events between the two groups up to 8 years (Figure).

CONCLUSIONS: In this study, hypertensive pts with LVH underwent PCI with DES was associated with higher cardiac mortality up to 8 years and need more careful management and clinical follow-up.