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IFITMs: Important Factors In Trans-Mission of HIV-1.

Daniel Sauter, Frank Kirchhoff
Cell Host & Microbe 2016 October 13
IFITMs inhibit various enveloped viral pathogens in vitro, but their relevance in vivo has remained unclear. In this issue of Cell Host & Microbe, Foster et al. (2016) show that IFITMs constitute a barrier to HIV-1 transmission and that escape from adaptive immune responses increases viral sensitivity to IFITM restriction.

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