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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD + depletion.
ELife 2016 October 14
Overexpression of the NAD+ biosynthetic enzyme NMNAT1 leads to preservation of injured axons. While increased NAD+ or decreased NMN levels are thought to be critical to this process, the mechanism(s) of this axon protection remain obscure. Using steady-state and flux analysis of NAD+ metabolites in healthy and injured mouse dorsal root ganglion axons, we find that rather than altering NAD+ synthesis, NMNAT1 instead blocks the injury-induced, SARM1-dependent NAD+ consumption that is central to axon degeneration.
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