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Oncometabolite Accumulation and Epithelial-to-Mesenchymal Transition: The Turn of Fumarate.

Maxime Janin, Manel Esteller
Cell Metabolism 2016 October 12
Mutations to the Krebs cycle enzyme fumarate hydratase in cancer cells leads to an accumulation of the oncometabolite fumarate. Sciacovelli et al. (2016) demonstrate an epigenetically dependent epithelial-to-mesenchymal transition mediated by modulation of the miR-200 cluster and TET demethylation in response to fumarate accumulation.

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