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COMMENT
JOURNAL ARTICLE
Overcoming ATM Deficiency by Activating the NAD + /SIRT1 Axis.
Cell Metabolism 2016 October 12
In this issue, Fang et al. (2016) show that both the DNA repair defect and mitochondrial dysfunction in ATM-/- cells or mice are mitigated by the anti-aging compound nicotinamide riboside or a SIRT1 activator. This broad suppression by activating the NAD+ /SIRT1 axis may generally apply to diseases and aging maladies.
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