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Chloromethyl-triazole: a new motif for site-selective pseudo-acylation of proteins.
Chemical Communications : Chem Comm 2016 October 7
Rapid, site-selective modification of cysteine residues with chloromethyl-triazole derivatives generates pseudo-acyl sLys motifs, mimicking important post-translational modifications. Near-native biotinylation of peptide and protein substrates is shown to be site-selective and modified histone H4 retains functional activity.
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