Depression and anxiety mediate the relationship between temperament and character and psychotic-like experiences in healthy subjects.

In this study we examined the hypothesis that depression and anxiety may mediate the relationship between personality traits and both positive and negative psychotic-like experiences (PLEs) in healthy adults. The Community Assessment of Psychic Experiences (CAPE) scale, Temperament and Character Inventory (TCI), Beck Depression Inventory (BDI) and State and Trait Anxiety Inventory (STAI) were administered to 492 healthy individuals. Multiple stepwise regression and mediation analyses were performed to examine whether depressive and anxiety symptoms influence the relationship between the TCI dimensions and positive and negative PLEs. Self-transcendence, persistence, novelty-seeking and self-directedness significantly predicted positive PLEs; self-directedness and harm avoidance were predictable for negative PLEs. Self-transcendence, self-directedness, persistence and harm avoidance also predicted the distress caused by positive PLEs, whereas self-directedness and harm avoidance predicted distress raised by negative PLEs. Depressive symptoms and the state of anxiety partially mediated the linkage between self-directedness and positive PLEs, and between self-directedness, harm avoidance and negative PLEs. Our findings confirm that the personality pattern influences both positive and negative PLEs as well as distress caused by experiencing positive and negative PLEs, and they indicate that certain personality traits may influence the development of PLEs via the emotional pathway of heightened depression and anxiety.