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Journal Article
Mitochondrial Diseases: Shortcuts to Therapies and Therapeutic Shortcuts.
Molecular Cell 2016 October 7
In this issue of Molecular Cell, Barrow et al. (2016) use two complementary approaches-one an assessment of a chemical library, and the other a genome-wide CRISPR screen-that both identify bromodomain-containing protein 4 (Brd4) as a therapeutic target for mtDNA diseases affecting complex I.
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