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Quantitative Systems Pharmacology: A Case for Disease Models.

C J Musante, S Ramanujan, B J Schmidt, O G Ghobrial, J Lu, A C Heatherington
Clinical Pharmacology and Therapeutics 2017 January
Quantitative systems pharmacology (QSP) has emerged as an innovative approach in model-informed drug discovery and development, supporting program decisions from exploratory research through late-stage clinical trials. In this commentary, we discuss the unique value of disease-scale "platform" QSP models that are amenable to reuse and repurposing to support diverse clinical decisions in ways distinct from other pharmacometrics strategies.

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