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Blood Assay Predicts Response to Pembrolizumab.
Cancer Discovery 2016 November
Researchers found that the magnitude of reinvigoration of CD8+ T cells-the peak level of Ki67 after treatment-compared with tumor burden prior to treatment with the PD-1 inhibitor pembrolizumab correlated with clinical response in patients with advanced melanoma. If this finding is confirmed in a larger cohort of patients, the ratio of these two factors could be used to determine whether a patient should continue with pembrolizumab therapy or switch to a different treatment or combination of treatments.
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