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JOURNAL ARTICLE
REVIEW
Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.
Biochemistry. Biokhimii︠a︡ 2016 September
Fibrillarin is one of the most studied nucleolar proteins. Its main functions are methylation and processing of pre-rRNA. Fibrillarin is a highly conserved protein; however, in the course of evolution from archaea to eukaryotes, it acquired an additional N-terminal glycine and arginine-rich (GAR) domain. In this review, we discuss the evolution of fibrillarin structure and its relation to the functions of the protein in prokaryotes and eukaryotes.
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