E3. Maternal haemodynamics follow-up after pregnancies complicated by HDP and/or IUGR.

AIMS: To compare maternal hemodynamic profile during pregnancy and at 6-12 months after delivery in pregnancies with different HDP phenotypes or severe IUGR.

METHODS: We enrolled patients between 24 and 38 weeks of gestation: HDP with appropriate for gestational age foetuses (HDP-AGAf), HDP with IUGR (HDP-IUGR), severe IUGR and Controls matched for gestational age. Severe IUGR was defined as abdominal circumference <5th centile and a PI in umbilical artery42SD. Diagnosis of HDP was made according to the criteria of the ISSHP. Maternal echocardiography was performed during pregnancy and at 6-12 months after delivery to compare in each group cardiac output (CO), total vascular resistance (TVR) and tissue Doppler E'/A' wave ratio.

RESULTS: Maternal heart rate and CO were reduced and TVR increased during pregnancy, and did not change significantly at follow-up in the 10 HDP-IUGR and in the 8 severe IUGR recruited. Heart rate, CO and TVR in the 8 HDP-AGAf were similar to Controls both during pregnancy and at follow-up except for a significantly increased MAP and a reduced E'/A' ratio.

DISCUSSION: Maternal hemodynamic changes at 6-12 months postpartum varies according to different physio-pathological phenotypes of maternal HDP and placental damage.