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Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Antigen-Specific Development of Mucosal Foxp3+RORγt+ T Cells from Regulatory T Cell Precursors.
Journal of Immunology 2016 November 2
Foxp3+ retinoic acid-related orphan receptor (ROR)γt+ T cells have recently been characterized as an immunoregulatory population highly enriched in the colon lamina propria. However, their developmental origin and relationship to RORγt- regulatory T and Th17 cells remain unclear. In this study, we use a fixed TCRβ system to show that the TCR repertoire of the Foxp3+ RORγt+ population is mostly distinct compared with other colonic T cell subsets. However, of these TCRs, a fraction is also found in the Th17 subset, suggesting that TCR repertoire overlap may contribute to the reported ability of Foxp3+ RORγt+ cells to regulate Th17 immunity. Naive transgenic T cells expressing a Foxp3+ RORγt+ -restricted TCR first acquire a Foxp3+ RORγt- phenotype before coexpressing RORγt, suggesting that Foxp3+ RORγt+ cell development can occur via an RORγt- regulatory T cell intermediate.
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