We have located links that may give you full text access.
A Self-Assembled Sensor for Carbohydrates on the Surface of Cyclodextrin Vesicles.
Chemistry : a European Journal 2017 May 3
A supramolecular carbohydrate sensor was prepared by self-assembly of unilamellar bilayer vesicles of amphiphilic β-cyclodextrin with a boronic acid-adamantane conjugate (PBA-AD), which binds strongly to β-cyclodextrin through host-guest interactions (Ka ≈4×104 m-1 ), so the vesicle surface exhibits multiple boronic acid receptors for carbohydrates. The binding of diols to the functionalized vesicles was tested with alizarin red S (ARS) as a reporter dye by using fluorescence and UV/Vis spectroscopy. Analysis of the competitive binding of monosaccharides revealed pH-dependent (pH 7.4-10.1) binding constants in the range of 100-3000 m-1 for d-fructose and 5-400 m-1 for d-glucose. Interestingly, the self-assembled sensor showed fluorescence intensity enhanced by about fivefold and a binding affinity to the reporter dye increased by about eightfold in comparison to PBA-AD and ARS without vesicles. This is attributed to increased local concentration of ARS and PBA-AD on the surface of the vesicles. Detection of d-fructose and d-glucose was possible in the physiologically relevant range in dilute aqueous solution.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app