We have located links that may give you full text access.
Goat K222-PrP(C) polymorphic variant does not provide resistance to atypical scrapie in transgenic mice.
Veterinary Research 2016
Host prion (PrP(C)) genotype is a major determinant for the susceptibility to prion diseases. The Q/K222-PrP(C) polymorphic variant provides goats and mice with high resistance against classical scrapie and bovine spongiform encephalopathy (BSE); yet its effect against atypical scrapie is unknown. Here, transgenic mice expressing the goat wild-type (wt) or the K222-PrP(C) variant were intracerebrally inoculated with several natural cases of atypical scrapie from sheep and goat and their susceptibility to the prion disease was determined. Goat wt and K222-PrP(C) transgenic mice were 100% susceptible to all the atypical scrapie isolates, showing similar survival times and almost identical disease phenotypes. The capacity of the K222-PrP(C) variant to replicate specifically the atypical scrapie strain as efficiently as the goat wt PrP(C), but not the classical scrapie or cattle-BSE as previously reported, further suggests the involvement of concrete areas of the host PrP(C) in the strain-dependent replication of prions.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app