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Continuous chromosomal instability in human pluripotent stem cells - the role of DNA replication.
Molecular & Cellular Oncology 2016 July
Human pluripotent stem cells (hPSCs) frequently acquire chromosomal aberrations, including aneuploidy, during culture. Recently, we identified a replication stress-based mechanism leading to ongoing chromosomal instability in aneuploid hPSCs that may also operate during the initiation of instability in diploid cells.
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