OS 04-08 THE RELATIONSHIP BETWEEN CHILDHOOD RISK FACTORS AND LONG-TERM ARTERIAL STIFFNESS - A 26-YEAR FOLLOW-UP STUDY.

OBJECTIVE: To explore the relationship between childhood risk factors and long-term arterial stiffness.

DESIGN AND METHOD: A baseline survey was carried out in 4623 school children aged 6-15 years in rural areas of Hanzhong city, Shaanxi in 1987. According to three measurements of systolic blood pressure (SBP) in 1987,1989 and 1992, high blood pressure group (HBP group) was defined as SBP ≥ 75 percentile at same age and gender, with SBP < 50 percentile as normal blood pressure group (NBP group). The cohort was followed up again 26-years later (in 2013), At the same time, Blood biochemistry indexes were measured, including fasting glucose, uric acid and blood lipid. Brachial-ankle pulse wave velocity (baPWV) was recorded by noninvasive automatic waveform analyzer.

RESULTS: The follow-up rate was 71.6%. HBP group versus NBP group had higher incidence of hypertension (39.5% vs.18.0%, P = 0.001) and baPWV [(1337.2 ± 198.3) vs. (1271.7 ± 204.3) cm/s, P = 0.028] in this follow-up period. Correlation analysis indicated that the follow-up baPWV was positively correlated with childhood SBP and SBP, DBP, body mass index, heart rate, TC, LDL-C, TG, fasting glucose, uric acid in adulthood (all P < 0.05). In stepwise multivariate regression analysis, gender, family history of hypertension, SBP at both baseline and follow-up, fasting glucose and uric acid in adulthood were independent predictive factors of baPWV in adults.

CONCLUSIONS: Higher SBP in children and adolescents, family history of hypertension and male gender may increase the risk of developing long-term arterial stiffness.