OS 31-04 COMPARISON OF CALCIUM CHANNEL BLOCKERS VERSUS CALCIUM CHANNEL BLOCKERS WITH RENIN ANGIOTENSIN SYSTEM BLOCKERS ON THE DEVELOPMENT OF NEW-ONSET DIABETES MELLITUS IN HYPERTENSIVE PATIENTS.

OBJECTIVE: Recently several studies reported that anti-hypertensive drugs were associated with development of new-onset diabetes mellitus (NODM). However, data on the relationship between detailed prescription types and long-term incidence of NODM are still limited in Asian patients (pts).

DESIGN AND METHOD: A total of 3,208 consecutive hypertension pts prescribed with calcium channel blockers (CCB) were enrolled with the exclusion of diabetic pts. Pts were divided into two groups according to the additional prescription of renin angiotensin system (RAS) blockers; 1) the CCB group (n = 1,987) and 2) CCB + RAS group (n = 1,221). To adjust for potential confounders, a propensity score matching (PSM) analysis was performed using the logistic regression model. Primary end-point was new-onset DM, defined as a fasting blood glucose ≥ 126 or HbA1c ≥ 6.5%. Additionally, individual and composite major adverse cerebro-cardiac events (MACCE) were compared between the two groups up to 5 years.

RESULTS: After PSM analysis, two propensity-matched groups (939 pairs, n = 1878, C-statistic = 0.743) were generated and the baseline characteristics of the two groups were balanced. Up to 5 years, there was no significant difference in the incidence of NODM, total death, myocardial infarction, percutaneous coronary intervention (PCI) and composite MACCE between the two groups, except that the CCB group showed higher incidence of stroke compared with the CCB + RAS group (table).

CONCLUSIONS: In our study, non-diabetic hypertensive pts given CCB or CCB + RAS did not differ in the incidence of NODM and adverse cardiovascular events up to 5 years.