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Epigenetic Control of Reprogramming and Transdifferentiation by Histone Modifications.

Hua Qin, Andong Zhao, Cuiping Zhang, Xiaobing Fu
Stem Cell Reviews 2016 December
Somatic cells can be reprogrammed to pluripotent stem cells or transdifferentiate to another lineage cell type. Much efforts have been made to unravel the epigenetic mechanisms underlying the cell fate conversion. Histone modifications as the major epigenetic regulator are implicated in various aspects of reprogramming and transdifferentiation. Here, we discuss the roles of histone modifications on reprogramming and transdifferentiation and hopefully provide new insights into induction and promotion of the cell fate conversion by modulating histone modifications.

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