Ca 19-9 Could Predict both Advanced Disease and Nodal Involvement in Primary Mucinous Endometrial Cancers.

Objective: Mucinous endometrial carcinoma is a rare disease. A study to evaluate and find predictive factors of mucinous endometrial carcinoma for advanced disease and nodal involvement was performed.

Methods: Patients who were operated at the Gynecologic Oncology Department of Zekai Tahir Burak Women's Health, Education and Research Hospital between January 2006 and January 2013 were evaluated and patients with primary mucinous endometrial carcinoma were retrospectively analysed.

Results: A total of 16 primary mucinous endometrial carcinoma patients were detected. Patients were evaluated into two groups according to stage. Group 1 was consisted of stage IA patients and group 2 was consisted of patients with higher stages than 1A (advanced disease). Twelve patients (75%) were stage IA whereas four patients (25%) were having higher than stage IA disease. Lymph node metastasis and lymphovascular space invasion (LVSI) were significantly positive in advanced disease (p = 0.011 and p = 0.01, respectively). Ca 125 and Ca 19-9 levels were also significantly elevated in patients with advanced disease (p = 0.021 and p = 0.039). On the other hand only Ca 19-9 was significantly elevated in the patients with nodal metastasis.

Conclusion: Pre-operative work-up of Ca-19.9 could predict both advanced disease and lymph node metastasis for mucinous endometrial cancers.