Hepatitis B Virus Reactivation after Autologous Haematopoietic Stem-cell Transplantation in a Hepatitis B urface Antigen-negative Patient.

A 58-year-old female patient whose serological test results were Hepatitis B surface antigen (HBsAg) negative and Hepatitis B surface antibody (HBsAb) positive, diagnosed with Multiple myeloma. Autologous haematopoietic stem-cell transplantation was subsequently performed after induction chemotherapy. One-year later the patient was diagnosed as Hepatitis B Virus (HBV) reactivation and was started on lamivudine oral therapy. Hepatitis B surface antigen (HBsAg) negative is negative and HBsAb is positive in patients scheduled for chemotherapy, HBV DNA levels should still be investigated. Patients in the risk group should be started on prophylactic antiviral therapy. Lamivudine can be used in treatment in patients who have not received prophylactic antiviral therapy who develop HBV reactivation during or after chemotherapy.