Cardiovascular Risk Assessment of Subclinical Hypothyroid Patients by Using Framingham Risk Score.

Objectives: The aim of this study is to evaluate the variation of cardiovascular risks of subclinical hypothyroid patients with thyroid hormone replacement therapy by using Framingham Risk Scoring system.

Materials and methods: In this study 21 subclinical hypothyroid and 22 healthy volunteers, between the ages 37 to 68 were taken as cases and control groups. Subclinical hypothyroid patients were given L-T4 replacement therapy for one-year to keep the thyroid hormone (TSH) values in normal ranges. Before and after the treatment clinical and laboratory parameters compared with each other for case and control groups.

Results: When we compared the pre and post treatment values of subclinical hypothyroid patients; The systolic and diastolic blood pressures, total cholesterol, low-density lipoprotein (LDL) cholesterol levels and framingham risk scores obviously decreased (p < 0.05). Although, at the begining of the study ten-year cardiovacular risk of the case group was significantly higher than that of control group, after treatment no difference was found between the two groups (p < 0.05 vs p > 0.05).

Conclusion: By using Framingham Risk Score, its obviously seen that in subclinical hypothyroid patients, just by thyroid hormone replacement therapy a marked decrease of cardiovascular risk can be obtained.