Correlation between Anaemia and Hepcidin-25 and Interleukin 6 Levels in Early Stage and Advanced Chronic Renal Disease.

Background: Anaemia is very commonly seen complication in the patients with chronic renal disease (CRD). This is thought to result from decreased renal excretion of the hepcidin and chronic inflammatory process. Our study aimed to investigate the correlation between haemoglobin (Hb) and hepcidin levels in all stages starting from stage 2 chronic renal disease (CRD).

Method: The study was conducted on a total of 80 patients with stage 2-3-4-5 CRD who have not been treated with renal replacement therapy, including 20 patients from each stage. In all groups, C-reactive protein (CRP), high sensitivity C-reactive protein (HsCRP), interleukin 6 (IL 6), hepcidin-25, routine biochemistry, whole blood count, iron, total iron binding capacity (TIBC), ferritin, folic acid and Vitamin B12 were measured.

Results: When the patients were evaluated for inflammatory parameters, CRP (p = 0.01), HsCRP (p = 0.01), erythrocyte sedimentation rate [ESR] (p = 0.001), IL 6 (p = 0.001), ferritin (p = 0.02), hepcidin-25 (p = 0.03) levels were significantly higher in the group with advanced stage compared to the group with early stage. It was determined that haemoglobin (Hb) level was statistically significantly lower in advanced CRD compared to early stage CRD (p < 0.001).

Conclusion: Using the agents that may decrease the levels of hepcidin may be useful to increase Hb levels in the treatment of anaemia in the patients with chronic renal disease.