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Study of Association of Atherosclerotic Risk Factors and Metabolic Syndrome in Patients of Psoriasis at a Tertiary Care Centre in North India: A Case Control Study.

OBJECTIVE: To study the association between psoriasis and atherosclerotic risk factors, including metabolic syndrome.

METHODS: Fifty patients with psoriasis and 50 controls were included in the study. Atherosclerotic risk factors were evaluated as per National Cholesterol Education Project Adult Treatment Panel III (NCEP-ATPIII). Metabolic syndrome was diagnosed as per South Asian Modified -National Cholesterol Education Programme's Adult Treatment Panel III (ATP III).

RESULTS: Psoriatic patients had a significantly higher prevalence of hypertriglyceridaemia (≥150 mg/dl) (p=0.013), low HDL (< 40mg/dl) (p=0.025), impaired fasting blood glucose (≥100 mg/dl) (p=0.026). Metabolic syndrome was present in significant number of psoriasis patients than in controls [42 (28%) versus 9 (6%)] (P=0.009).

CONCLUSIONS: There is a significantly higher prevalence of metabolic syndrome and atherosclerotic risk factors in psoriasis patients as compared to controls.

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